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Key Publications & Recommended Reading
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1. Wraith, D.C., McDevitt, H.O., Steinman, L. & Acha-Orbea, H. T cell recognition as the target for immune intervention in autoimmune disease. Cell (1989) 57:709-715.
2. Wraith, D.C., Smilek, D.E., Mitchell, D.J., Steinman, L. & McDevitt, H.O. Antigen recognition in autoimmune encephalomyelitis and the potential for peptide mediated immunotherapy. Cell (1989) 59: 247-255.
3. Metzler, B. and Wraith, D.C. Inhibition of experimental autoimmune encephalomyelitis by inhalation but not oral administration of the encephalitogenic peptide: influence of MHC binding affinity. International Immunology (1993) 5, 1159-1165.
4. Hoyne, G.F., O'Hehir, R.E., Wraith, D.C., Thomas, W.R. and Lamb, J.R. Inhibition of T-cell and antibody responses to house dust mite allergen by inhalation of the dominant T-cell epitope in naive and sensitised mice. J. Exp. Med. (1993) 178, 1783-1788.
5. Liu, G.Y., and Wraith, D.C. Affinity for class II MHC determines the extent to which soluble peptide tolerize autoreactive T cells in naive and primed adult mice - implications for autoimmunity. International Immunology (1995) 7, 1255-1263.
6. Liu, G.Y., Fairchild, P.J., Smith, R.M., Prowle, J.R., Kioussis, D., and Wraith, D.C. Low avidity recognition of self-antigen by T cells permits escape from central tolerance. Immunity (1995) 3, 407-415.
7. Anderton S.M. & Wraith D.C. Hierarchy in the ability of T cell epitopes to induce peripheral tolerance to antigens from myelin. Eur. J. Immunol. (1998) 28, 1251-1261.
8. Metzler, B. & Wraith, D.C. Inhibition of T cell responsiveness by nasal peptide administration: Influence of the thymus and differential recovery of T cell-dependent functions. Immunology (1999) 97, 257-263.
9. Burkhart C., Liu G.Y., Metzler B. & Wraith D.C. Peptide-induced T cell regulation of autoimmunity: a role for interleukin-10. Int. Immunol. (1999) 11, 1625-1634.
10. Anderton, S., Burkhart, C., Metzler, B. & Wraith, D. Mechanisms of central and peripheral T-cell tolerance: lessons from experimental models of multiple sclerosis. Immunol. Rev. (1999) 169, 123-137.
11. Metzler, B., Anderton, S.M., Manickasingham, S.P. & Wraith, D.C. Kinetics of peptide uptake and tissue distribution following a single tolerogenic intranasal dose of peptide. Immunological Investigations (2000) 29, 61-70.
12. Anderton, S.M., Radu, C.G., Lowrey, P.A., Ward, E.S. and Wraith D.C. Negative selection during the peripheral immune response to antigen J. Exp. Med. (2001) 193 (1), 1-11.
13. Ponsford, M., Mazza, G., Coad, J., Campbell, M.J., Zajicek, J. and Wraith, D.C. Differential responses of CD45+ve T-cell subsets to MBP in multiple sclerosis. Clin. Exp. Immunol. (2001) 124, 315-322.
14. Mazza, G., Ponsford, M., Coad, J., Campbell, M.J., Zajicek, J. and Wraith, D.C. Diversity and dynamics of the T cell response to MBP in DR2+ve individuals. Clin. Exp. Immunol (2002) 128, 538-547.
15. Anderton, S.M., Viner, N.J., Matharu, P., Lowrey, P.A. and Wraith D.C. The influence of a dominant cryptic epitope on autoimmune T cell tolerance. Nature Immunology (2002) 3, 175-181.
16. Wraith, D.C. Vaccines for the treatment of autoimmune diseases. In New Generation Vaccines, an international textbook, volume 3. Chapter 86. Editors: Myron M. Levine, James B. Kaper, Rino Rappuoli, Margaret Liu, Michael Good. (2003)
17. Sunstedt, A., O’Neill, E.J., Nicolson, K.S., Wraith, D.C. Role for IL-10 in suppression mediated by peptide-induced regulatory T-cells in vivo. Journal of Immunology (2003) 170, 1240-1248.
18. Shen, C-R., Youssef, R., Devine, A., Bowie, L., Hall, A.M., Wraith, D.C., Elson, C.J. & Barker, R.N. Peptides containing a dominant T-cell epitope from red cell Band 3 have in vivo immunomodulatory properties in NZB mice with autoimmune hemolytic anemia. Blood (2003) 102, 3800-3806.
19. Vieira, P.L., Christensen, J.R., Minaee, S., O’Neill, E.J., Barrat, F.J., Boonstra, A., Barthlott, T., Stockinger, B., Wraith, D.C. & O’Garra, A. IL-10-Secreting Regulatory T Cells Do Not Express Foxp3 but Have Comparable Regulatory Function to Naturally Occurring CD4+CD25+ Regulatory T Cells. Journal of Immunology (2004) 172, 5986 - 5993.
20. Wraith, D.C., Nicolson, K.S. & Whitley, N.T. Regulatory CD4+ T cells and the control of autoimmune disease. Current Opinion in Immunology (2004) 16, 695-701.
21. Larche, M. and Wraith, D.C. Tolerising Vaccines for Allergic and Autoimmune Diseases Nature Medicine (2005) 11, S69-S76
22. Wraith, D.C. Peptide based therapy for autoimmune disease. Drug Discovery Today: Therapeutic Strategies (2006) 3, 35-40
23. Nicolson, K.S., O’Neill, E.J., Sundstedt, A., Streeter, H.B., Minaee, S. and Wraith, D.C. Antigen-induced IL-10+ regulatory T cells are independent of CD25+ regulatory cells for their growth, differentiation and function. Journal of Immunology (2006) 176: 5329-5337.
24. Anderson, P.O., Manzo, B.A., Sundstedt, A., Minaee, S., Symonds, A., Khalid, S., Rodriguez-Cabezas, M.E., Nicolson, K., Li, S., Wraith, D.C., Wang P. Persistent antigenic stimulation alters the transcription program in T cells resulting in antigen specific tolerance. Eur. J. Immunol. (2006) 36:1374-1385.