Publications
Key Publications & Recommended Reading
Wraith, D.C., McDevitt, H.O., Steinman, L. & Acha-Orbea, H. T cell recognition as the target for immune intervention in autoimmune disease. Cell (1989) 57:709-715.
Wraith, D.C., Smilek, D.E., Mitchell, D.J., Steinman, L. & McDevitt, H.O. Antigen recognition in autoimmune encephalomyelitis and the potential for peptide mediated immunotherapy. Cell (1989) 59: 247-255.
Metzler, B. and Wraith, D.C. Inhibition of experimental autoimmune encephalomyelitis by inhalation but not oral administration of the encephalitogenic peptide: influence of MHC binding affinity. International Immunology (1993) 5, 1159-1165.
Hoyne, G.F., O'Hehir, R.E., Wraith, D.C., Thomas, W.R. and Lamb, J.R. Inhibition of T-cell and antibody responses to house dust mite allergen by inhalation of the dominant T-cell epitope in naive and sensitised mice. J. Exp. Med. (1993) 178, 1783-1788.
Liu, G.Y., and Wraith, D.C. Affinity for class II MHC determines the extent to which soluble peptide tolerize autoreactive T cells in naive and primed adult mice - implications for autoimmunity. International Immunology (1995) 7, 1255-1263.
Liu, G.Y., Fairchild, P.J., Smith, R.M., Prowle, J.R., Kioussis, D., and Wraith, D.C. Low avidity recognition of self-antigen by T cells permits escape from central tolerance. Immunity (1995) 3, 407-415.
Anderton S.M. & Wraith D.C. Hierarchy in the ability of T cell epitopes to induce peripheral tolerance to antigens from myelin. Eur. J. Immunol. (1998) 28, 1251-1261.
Metzler, B. & Wraith, D.C. Inhibition of T cell responsiveness by nasal peptide administration: Influence of the thymus and differential recovery of T cell-dependent functions. Immunology (1999) 97, 257-263.
Burkhart C., Liu G.Y., Metzler B. & Wraith D.C. Peptide-induced T cell regulation of autoimmunity: a role for interleukin-10. Int. Immunol. (1999) 11, 1625-1634.
Anderton, S., Burkhart, C., Metzler, B. & Wraith, D. Mechanisms of central and peripheral T-cell tolerance: lessons from experimental models of multiple sclerosis. Immunol. Rev. (1999) 169, 123-137.
Metzler, B., Anderton, S.M., Manickasingham, S.P. & Wraith, D.C. Kinetics of peptide uptake and tissue distribution following a single tolerogenic intranasal dose of peptide. Immunological Investigations (2000) 29, 61-70.
Anderton, S.M., Radu, C.G., Lowrey, P.A., Ward, E.S. and Wraith D.C. Negative selection during the peripheral immune response to antigen J. Exp. Med. (2001) 193 (1), 1-11.
Ponsford, M., Mazza, G., Coad, J., Campbell, M.J., Zajicek, J. and Wraith, D.C. Differential responses of CD45+ve T-cell subsets to MBP in multiple sclerosis. Clin. Exp. Immunol. (2001) 124, 315-322.
Mazza, G., Ponsford, M., Coad, J., Campbell, M.J., Zajicek, J. and Wraith, D.C. Diversity and dynamics of the T cell response to MBP in DR2+ve individuals. Clin. Exp. Immunol (2002) 128, 538-547.
Anderton, S.M., Viner, N.J., Matharu, P., Lowrey, P.A. and Wraith D.C. The influence of a dominant cryptic epitope on autoimmune T cell tolerance. Nature Immunology (2002) 3, 175-181.
Wraith, D.C. Vaccines for the treatment of autoimmune diseases. In New Generation Vaccines, an international textbook, volume 3. Chapter 86. Editors: Myron M. Levine, James B. Kaper, Rino Rappuoli, Margaret Liu, Michael Good. (2003)
Sunstedt, A., O’Neill, E.J., Nicolson, K.S., Wraith, D.C. Role for IL-10 in suppression mediated by peptide-induced regulatory T cells in vivo. Journal of Immunology (2003) 170, 1240-1248.
Shen, C-R., Youssef, R., Devine, A., Bowie, L., Hall, A.M., Wraith, D.C., Elson, C.J. & Barker, R.N. Peptides containing a dominant T-cell epitope from red cell Band 3 have in vivo immunomodulatory properties in NZB mice with autoimmune hemolytic anemia. Blood (2003) 102, 3800-3806.
Vieira, P.L., Christensen, J.R., Minaee, S., O’Neill, E.J., Barrat, F.J., Boonstra, A., Barthlott, T., Stockinger, B., Wraith, D.C. & O’Garra, A. IL-10-Secreting Regulatory T Cells Do Not Express Foxp3 but Have Comparable Regulatory Function to Naturally Occurring CD4+CD25+ Regulatory T Cells. Journal of Immunology (2004) 172, 5986 - 5993.
Wraith, D.C., Nicolson, K.S. & Whitley, N.T. Regulatory CD4+ T cells and the control of autoimmune disease. Current Opinion in Immunology (2004) 16, 695-701.
Larche, M. and Wraith, D.C. Peptide Vaccines for Allergic and Autoimmune Diseases. Nature Medicine (2005) 11: s69-76.
Kurschus, F., Oelert, T. Liliensiek, B. Brocke, P. Wraith, D.C. Hammerling, G.J. and Arnold, B. Experimental autoimmune encephalomyelitis in Mice Expressing the Autoantigen MBP1-10 Covalently bound to the MHC Class II Molecule I-Au. International Immunology (2006) 18: 151-162.
Dawes, R. Petrova, S. Liu, Z., Wraith, D.C., Beverley, P.C.L. and Tchilian, E.Z. Combinations of CD45 isoforms are crucial for immune function and disease. Journal of Immunology (2006) 176: 3417-3425.
Wraith, D.C. Peptide based therapy for autoimmune disease. Drug Discovery Today: Therapeutic Strategies (2006) 3, 35-40.
Nicolson, K.S., O’Neill, E.J., Sundstedt, A., Streeter, H.B., Minaee, S. and Wraith, D.C. Antigen-induced IL-10+ regulatory T cells are independent of CD25+ regulatory cells for their growth, differentiation and function. Journal of Immunology (2006) 176: 5329-5337.
Anderson, P.O., Manzo, B.A., Sundstedt, A., Minaee, S., Symonds, A., Khalid, S., Rodriguez-Cabezas, M.E., Nicolson, K., Li, S., Wraith, D.C., Wang P. Persistent antigenic stimulation alters the transcription program in T cells resulting in antigen specific tolerance. Eur. J. Immunol. (2006) 36:1374-1385.
Nicolson, K.S. and Wraith, D.C. Natural and induced regulatory T cells: Targets for immunotherapy of autoimmune disease and allergy. Inflammation and Allergy - Drug Targets (2006) 5:141-148.
O’Neill, E.J., Day, M.J. and Wraith, D.C. IL-10 is essential for disease protection following intra-nasal peptide administration in the C57BL/6 model of EAE. Journal of Neuorimmunology (2006) 178: 1-8.
Wraith, D.C. Avidity and the art of self non-self discrimination. Immunity (2006) 25: 191-193.
Wraith, D.C. Anti-cytokine vaccines and the immunotherapy of autoimmune diseases. European Journal of Immunology (2006) 36:2844-2848.
Thomas, I.J., Petrich de Marquesini, L.G., Ravanan, R., Smith, R.M., Guerder, S., Flavell, R.A., Wraith, D.C., Wen, L. and Wong, F.S. CD86 Has Sustained Costimulatory Effects on CD8 T Cells. Journal of Immunology (2007) 179:5936-5946.
Dayan, C.M. and Wraith, D.C. Preparing for first-in-man studies: the challenges for translational immunology post-TNG1412. Clinical and Experimental Immunology (2008) 151: 231–234.
Verhagen, J., Sabatos, C.A. and Wraith, D.C. The role of CTLA-4 in immune regulation. Immunology Letters (2008) 115: 73-74.
Lüth, S., Huber, S., Schramm, C., Buch, T., Zander, S., Stadelmann, C., Brück, W., Wraith, D.C., Herkel, J. and Lohse, A.W. Ectopic expression of neural autoantigen in liver suppresses autoimmune neuroinflammation by inducing antigen-specific Treg cells. Journal of Clinical Investigation (2008) 118: 3403-3410.
O’Connor, R.A., Prendergast, C.T., Sabatos, C.A., Lau, C.W.Z., Leech, M.D., Wraith, D.C. and Anderton, S.M. T-helper 1 cells facilitate the entry of T-helper 17 cells to the central nervous system during experimental autoimmune encephalomyelitis. Journal of Immunology (2008) 181: 3750-3754
Zhu, B., Symonds, A.L.J., Martin, J.E., Kioussis, D., Wraith, D.C., Li, SL. and Wang P. Early growth response gene 2 (Egr-2) controls the self-tolerance of T cells and development of lupus like autoimmune disease. Journal of Experimental Medicine (2008) 205: 2295-2307
Hollander, A. P., and D. C. Wraith. Stem Cell Immunology. In Advances in Tissue Engineering. S. M. S. E. H. (2008) Julia Polak, ed. World Scientific Publishing, London, Chapter 10.
Gordon, D., Pavlovska, G., Glover, C.P., Uney, J.B., Wraith, D. and Scolding, N.J. Human mesenchymal stem cells abrogate experimental allergic encephalomyelitis after intraperitoneal injection and with sparse CNS infiltration. Neuroscience Letters (2008) 448: 71-73.
Wraith DC. Therapeutic peptide vaccines for treatment of autoimmune diseases. Immunol Lett (2009) 122, 134-136.
Verhagen, J., Gabrysova, L., Minaee, S., Sabatos, C.A., Anderson, G., Sharpe, A.H. and Wraith, D.C. Enhanced selection of FoxP3+ T-regulatory cells protects CTLA-4 deficient mice from CNS autoimmune disease. Proc. Natl. Acad. Sci. (USA) (2009) 106, 3306-3311.
Gabrysova, L., Nicolson, K.S., Streeter, H.B., Verhagen, J., Sabatos-Peyton, C.A., Morgan, D.J., and Wraith, D.C. Negative feedback control of the autoimmune response through antigen-induced differentiation of IL-10-secreting Th1 cells. Journal of Experimental Medicine (2009) 206: 1755-1767.
Wraith, D.C., Pope, R., Butzkueven, H., Holder, H., Vanderplank, P., Lowrey, P., Day, M.J., Gundlach, A.L., Kilpatrick, T.J., Scolding, N. and Wynick, D. A role for galanin in human and experimental inflammatory demyelination. Proc. Natl. Acad. Sci. (USA) (2009) 36: 15466-15471.
Willison, H.J. and Wraith, D.C. A hazardous vapour trail from abattoir to neuropathy clinic. Lancet Neurology (2010) 9: 22-24.
Mazza, G., Sabatos-Peyton, C., Protheroe, R. and Wraith, D.C. Isolation and characterization of human interleukin (IL)-10-secreting T cells from peripheral blood. Human Immunology (2010) 71: 225-234.
Gabrysova, L. and Wraith, D.C. Antigenic strength controls the generation of antigen-specific IL-10-secreting T regulatory cells (2010) European Journal of Immunology available on-line.
